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FABRICATION AND CHARACTERIZATION OF CONDUCTIVE SCAFFOLD BASED ON PVA/PPy
Poster Presentation
Authors
1Advanced Magnetic Materials Research center, School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran, Iran.
2Assistant professor, School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran, Iran
3Professor, Advanced Magnetic Materials Research Center, School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran, Iran
Abstract
Nanotechnology has a wide range of medical and industrial applications. Polypyrrole particles are one of the most promising types of conductive polymers for biomedical applications. Facile synthesis approaches, good electrical conductivity, ease of surface modification,mades PPy attractive for use in tissue engineering(TE) applications. PPy have promising prospects in this field due to good conductivity, stability and biocompatibility characteristics and have been of great interest during the last few years.
Tissue engineering is an interdisciplinary field integrating engineering, material science and medical biology that aims to develop biological substitutes to repair, replace, retain, or enhance tissue and organ-level functions. Tissue engineering scaffolds with magnetic or conductive properties may conduct electric or magnetic signals and bring out synergetic promoting effect to cells growth. Fabrication and optimization of conductive scaffolds capable of inducing proper intercellular connections through electrical signals is critical for neural tissue engineering.
The aim of this study was the design of a 3D conductive biocompatible and biodegradable scaffold composed of poly(vinyl) alcohol (PVA)/polypyrrole (PPy) microparticles via hybrid method to investigate effect of electrical stimulation for neural tissue engineering. The scaffold was fabricated using a combination of gas foaming and freeze-drying processes. The physico-chemical properties of the PVA/PPy scaffolds were investigated by Fourier transform infrared spectroscopy (FT-IR), Scaffolds morphology observed by using scanning electron microscopy (SEM).
Tissue engineering is an interdisciplinary field integrating engineering, material science and medical biology that aims to develop biological substitutes to repair, replace, retain, or enhance tissue and organ-level functions. Tissue engineering scaffolds with magnetic or conductive properties may conduct electric or magnetic signals and bring out synergetic promoting effect to cells growth. Fabrication and optimization of conductive scaffolds capable of inducing proper intercellular connections through electrical signals is critical for neural tissue engineering.
The aim of this study was the design of a 3D conductive biocompatible and biodegradable scaffold composed of poly(vinyl) alcohol (PVA)/polypyrrole (PPy) microparticles via hybrid method to investigate effect of electrical stimulation for neural tissue engineering. The scaffold was fabricated using a combination of gas foaming and freeze-drying processes. The physico-chemical properties of the PVA/PPy scaffolds were investigated by Fourier transform infrared spectroscopy (FT-IR), Scaffolds morphology observed by using scanning electron microscopy (SEM).
Keywords