Poster Presentation

¹Narges Ajalli; ¹Mehrab Pourmadadi; ²Fatemeh Yazdian ; ³Hamid Rashedi

¹School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran

²Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Tehran, Iran

³Department of Chemical Engineering, Faculty of Engineering, University of Tehran, Tehran, Iran

The main purpose of this study is the optimization and fabrication of bacterial cellulose-based on GO-Cu-Cur nanocomposite and PVA/GO-Cu-Cur as a wound dresser in order to accelerate the wound repairing process. First of all, graphene oxide, GO-Cu nanohybrid, and GO-Cu-Cur nanohybrid were synthesized, and by the were characterized. Then, the PVA/GO-Cu-Cur was synthesized by the electrospinning method, and by the FTIR was characterized. SEM analysis indicates that the diameter of the nanofibers is 328 nm. Mechanical characteristic of PVA/GO-Cu-Cur was investigated by the tensile resistance, and it reveals that the GO-Cu-Cur nanohybrid cause the improvement of mechanical characteristic. The bacterial cellulose/GO-Cu-Cur by the floating method was synthesized, and also, the biodegradable behavior of nanocomposite was optimized, and the sample shows a degradation percentage of 44% after 98 h. For investigation of the antibacterial effect of synthesized materials, the MIC and optical density (OD) were used. The results show that these materials have a great ability to inhibition of gram-negative and gram-positive bacteria growth. The toxicity, survival, and cell proliferation of the fibroblast cells by the MTT were investigated, and results show that the GO-Cu-Cur nanohybrid does not have a toxic effect. Therefore, the PVA/GO-Cu-Cur nanofiber is a promising wound dressing for inhibiting bacterial growth and promoting skin wound repair

bacterial cellulose; polyvinyl alcohol; Graphene oxide; Curcumin; cu nanoparticles