Home Proceedings
Heparin-coated poly (ethylene terephthalate)/graphene oxide nanofibers for vascular engineering: Morphology, hydrophilicity, electrical conductivity and blood platelet adhesion studies
Oral Presentation XML
Authors
1Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
2Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
3Nano-Biopolymers Research Laboratory, School of Chemical engineering, College of Engineering, University of Tehran, Tehran, Iran.
Abstract
A series of properties such as small diameter, hydrophilicity, electrical conductivity and blood platelets adhesion are indispensable for an artificial vascular graft. In this study, electrospun poly (ethylene terephthalate) (PET) nanofibers containing different contents of graphene oxide (GO) (0.5 and 3 %) were prepared to optimize. By the addition of 3 wt. % of GO to the PET nanofibers, the optimum average diameter of about 546 nm was obtained from the micrograph images. Moreover, the optimum sample exhibited the contact angle of 118° and electrical conductivity of 1.08 × 10-10 S/cm. Finally, to avoid thrombus formation, heparin (Hep) as a well-known anticoagulant agent was coated onto the surface of the sample and the partial thromboplastin time (PTT) results showed an increase in coagulation time (>300 s). Finally, the Hep-coated PET/GO-3 wt. % nanofibrous sample revealed a high potential for vascular tissue engineering applications.
Keywords