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Aspirin-loaded poly (ethylene terephthalate)/carbon nanotubes nanofibers used for vascular engineering applications potentially
Poster Presentation
Authors
1Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
2Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
Abstract
Deficient cell proliferation on vascular grafts can cause coronary thrombosis and despite all recent innovations in vascular tissue engineering, fabricating novel materials with superior hemocompatibility remains a challenge. In this work, poly (ethylene terephthalate) (PET)/carboxylated multi-walled carbon nanotubes (CMWCNT) nanofibers were prepared via electrospinning. The results showed that the optimum value of CMWCNT content was 1% which in turn the average diameter of nanofibers, electrical conductivity and water contact angle were obtained 188 nm, 4.47×10-9, and 120º, respectively. To assess the hemocompatibility of the PET/CMWCNT1% nanofibers, aspirin (2 wt. % per polymer weight) as an anticoagulant drug was used and outcomes revealed that the blood platelets adhesion spreading was less than that of sample without the drug.
Keywords