Poster Presentation

¹aryan najjari; ²Rouhollah Mehdinavaz Aghdam ; ³Seyed Ali Seyed Ebrahimi

¹School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, P.O. Box: 11155-4563, Tehran, Iran

²1School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, P.O. Box: 11155-4563, Tehran, Iran

³Advanced Magnetic Materials Research Center, College of Engineering, University of Tehran, Tehran, Iran

Cardiovascular disease is known as the major cause of death all around the world today. In the majority of cases, cardiovascular disease leads to myocardial infarction, heart attack, which can trigger heart failure and death. In these cases, the damaged part of the heart will become scar tissue and the heart has poor regeneration ability; by this way, tissue engineering is a suitable way for regenerating the scar tissue. Electrospinning is a promising method for fabricating scaffolds for cardiac tissue engineering. In this research, an electrospun nanofibrous hybrid scaffold was fabricated. This scaffold was based on alginate. In order to increase the mechanical properties and piezoelectric properties of the cited scaffold, PVDF was added to alginate. To prepare this scaffold, alginate solution and PVDF solution were prepared separately and then they transferred into two different syringes; then by the help of dual electrospinning these two solutions, with their own suitable rates, made the nanofibrous scaffold. The fabricated nanocomposite scaffold was analyzed by scanning electron microscopy (SEM) to determine the fiber diameter and evaluate the fiber morphology. Also, fourier transform infrared (FTIR) spectroscopy and Water Contact Angle test were done in this project to evaluate the properties of the fabricated hybrid scaffold.

Alginate; PVDF; Piezoelectric; cardiac tissue engineering