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Aspirin-loaded poly (ethylene terephthalate)/carbon nanotubes nanofibers used for vascular engineering applications potentially
Paper ID : 1098-UFGNSM2021-FULL (R1)
Oral / Poster Presentation File
Authors:
Chakavak Nojavan1, Payam Zahedi *1, Mahboubeh Kabiri2, Romina Sepehri1
1Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
2Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
Abstract:
Deficient cell proliferation on vascular grafts can cause coronary thrombosis and despite all recent innovations in vascular tissue engineering, fabricating novel materials with superior hemocompatibility remains a challenge. In this work, poly (ethylene terephthalate) (PET)/carboxylated multi-walled carbon nanotubes (CMWCNT) nanofibers were prepared via electrospinning. The results showed that the optimum value of CMWCNT content was 1% which in turn the average diameter of nanofibers, electrical conductivity and water contact angle were obtained 188 nm, 4.47×10-9, and 120º, respectively. To assess the hemocompatibility of the PET/CMWCNT1% nanofibers, aspirin (2 wt. % per polymer weight) as an anticoagulant drug was used and outcomes revealed that the blood platelets adhesion spreading was less than that of sample without the drug.
Keywords:
Carbon nanotubes, Poly (ethylene terephthalate), Aspirin, Nanofiber, Hemocompatibility
Status : Paper Published