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Synthesis of high-potential polymer-coated cobalt ferrite magnetic nanoparticles for biomedical applications
Paper ID : 1092-UFGNSM2021-FULL
Oral / Poster Presentation File
Authors:
mohammad poorhossein, Fatemeh Sadat Pishbin *, Abolghasem Ataie
School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran, Iran
Abstract:
Nanoparticles provide a novel platform for delivery of anticancer drugs to tumors site with decreased side effects. In this context, magnetic nanomaterials offer smart targeting for cancer therapy. Also, polymers have played an important role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. In this research, for the first time, a ternary biocompatible multifunctional nanocarrier by the combination of cobalt ferrite (CFO), polyaniline and polyethylene glycol (CoFe2O4, PANI, PEG) has been investigated.
CoFe2O4 is an interesting choice due to its high Curie temperature TC (520 °C), moderate saturation magnetization and high anisotropy constant. These properties make CoFe2O4 an ideal candidate for a range of medical applications. Drug-delivery vehicles can be coated with a hydrophilic polymer to allow both inhibition of opsonization and enhancement of water solubility.
Poly (ethylene glycol) (PEG) is the most commonly applied non-ionic hydrophilic polymer with stealth behavior. On the other hand, Polyaniline (PANI), as one of the most well-known conductive polymers, has outstanding potential applications in biomedicine because of its high electrical conductivity and biocompatibility caused by its hydrophilic nature, low-toxicity, good environmental stability, nanostructured morphology and high capacity of drug loading.
Cobalt ferrite was synthesized by a facile coprecipitation method and coated by polyaniline and polyethylene glycol via different chemical routes. The prepared samples were characterized using X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), scanning electron microscopy (SEM).
Thus, the nanocarriers designed in this work could be used as a novel multifunctional and synergistic platform for delivering different types of anti-cancer drugs and other biomedical applications especially in the field of cancer therapy.
Keywords:
Magnetic Materials; Polymers; Cobalt ferrite; Polyaniline; Polyethylene glycol; Drug delivery.
Status : Paper Published